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Magic-BLAST, an accurate RNA-seq aligner for long and short reads

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WebOct 16, 2024 · Next-generation sequencing technologies can produce tens of millions of reads, often paired-end, from transcripts or genomes. But few programs can align RNA on the genome and accurately discover introns, especially with long reads. We introduce Magic-BLAST, a new aligner based on ideas from the Magic pipeline. It uses innovative … WebJun 16, 2024 · Table 4 Aligner parameters used in the evaluation Full size table 5 The mapping is a string-matching problem. It needs to integrate the known properties of the DNA sequences with the sequencing technologies, increasing … WebAt the best F-score, Magic-BLAST has the highest F-score in 15 experiments, plus the 12 duplicate benchmarks. The only exception is the human T1 truncated at 50+50, where … how did mammoths go extinct