Paloma-2 trial
WebApr 19, 2016 · PALOMA-2 is a randomized (2:1), multicenter, multinational, double-blind Phase 3 study designed to assess PFS in postmenopausal women with ER+, HER2- advanced breast cancer receiving IBRANCE (125 mg orally once daily for three out of four weeks in repeated cycles) in combination with letrozole (2.5 mg once daily continuously) …
Paloma-2 trial
Did you know?
WebAbstract Background: PALOMA-2 confirmed that first-line palbociclib + letrozole improved progression-free survival (hazard ratio, 0.58; 95% confidence interval, 0.46-0.72) in postmenopausal women with estrogen receptor-positive (ER+)/human epidermal growth factor receptor 2-negative (HER2-) advanced breast cancer (ABC). WebDec 6, 2024 · PALOMA-2 is a randomized (2:1), multicenter, multinational, double-blind Phase 3 study designed to assess the PFS of IBRANCE (125 mg orally once daily for three out of four weeks in repeated cycles) in combination with letrozole (2.5 mg once daily continuously) versus letrozole plus placebo as a first-line treatment for postmenopausal …
WebMay 24, 2024 · The purpose of the study is to simplify amivantamab intravenous administration and to reduce dose times, by assessing a new formulation of amivantamab, amivantamab subcutaneous and co-formulated with recombinant human hyaluronidase (SC-CF), for subcutaneous administration. WebMar 22, 2024 · In addition, PALOMA-2 reported 22% of the trial population had a DFI < 12 months, compared to 1% in MONALEESA-2 13,15. However, it is important to note that different definitions of DFI and ...
WebIn the PALOMA-2 trial, 666 postmenopausal patients with no prior systemic therapy for metastatic breast cancer were randomised 2:1 to receive palbociclib (same schedule than in the above-mentioned studies) combined with an AI (letrozole) or placebo +letrozole until disease progression, consent withdrawal or death. WebOther trials also investigating CDK4/6 inhibitors as first-line therapy in postmenopausal patients (PALOMA-2 and MONARCH 3) have yet to report final overall survival.
WebAug 16, 2024 · PALOMA-2 was a phase 3 study of palbociclib and letrozole as first-line therapy for postmenopausal women with ER + , human epidermal growth factor receptor 2–negative (HER2–) advanced breast...
WebOct 28, 2024 · A Study of Amivantamab Subcutaneous (SC) Administration for the Treatment of Advanced Solid Malignancies (PALOMA) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. food lion 3860 s new hope rd gastonia ncWebThe designs of the MONALEESA-2 and PALOMA-2/PALOMA-1 trials were similar and were, therefore, considered suitable for comparison. Of the MONALEESA-2 ITT population, 334 patients were treated with RIBO and LET and 334 patients were treated with placebo and LET. In the PALOMA-2 trial, 444 patients were treated with PALBO and LET and … elder sister and younger brother relationWebMay 20, 2016 · In PALOMA-1, an open-label Ph 2 trial, addition of P to L improved median PFS vs L alone (20.2 months [mo] vs 10.2 mo) in pts with first-line ER+/HER2– ABC with … food lion 38th 29577WebSep 13, 2013 · Treatment effect of palbociclib plus endocrine therapy by prognostic and intrinsic subtype and biomarker analysis in patients with bone-only disease: a joint analysis of PALOMA-2 and PALOMA-3 clinical trials. Breast Cancer Res Treat. 2024 Nov;184(1):23-35. doi: 10.1007/s10549-020-05782-4. Epub 2024 Aug 11. elder sister cuddling with baby brotherWebDec 4, 2012 · A Study of Palbociclib (PD-0332991) + Letrozole vs. Letrozole For 1st Line Treatment Of Postmenopausal Women With ER+/HER2- Advanced Breast Cancer … food lion 5592 staples mill plazaWebThe designs of the MONALEESA-2 and PALOMA-2/PALOMA-1 trials were similar and were, therefore, considered suitable for comparison. Of the MONALEESA-2 ITT … elders in warrior catsWebJun 4, 2024 · NEW YORK, June 04, 2024 -- ( BUSINESS WIRE )--Pfizer Inc. (NYSE:PFE) today announced overall survival (OS) results from the Phase 3 PALOMA-2 trial, which … food lion 5 gallon water