Topotecan sicherheitsdatenblatt
WebApr 1, 2024 · Descriptions. Topotecan injection is used to treat patients with metastatic cancer (a cancer that has already spread) of the ovaries after other treatments have failed. This medicine is also used to treat a certain type of lung cancer called small cell lung cancer. It is also used in combination with cisplatin to treat cancer of the cervix that ... WebJun 1, 2000 · The results of a new study demonstrate that one-third of patients with recurrent ovarian cancer who are categorized as platinum-sensitive respond to treatment with topotecan (Hycamtin). The multicenter trial, conducted by the Gynecologic Oncology Group (GOG) and published in the March issue of the Journal of Clinical Oncology, is the …
Topotecan sicherheitsdatenblatt
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WebTopotecan comes as a liquid to be given intravenously (into a vein) over 30 minutes by a doctor or nurse in a hospital or clinic. When topotecan injection is used to treat ovarian or … WebPharmacodynamics. Topotecan, a semi-synthetic derivative of camptothecin (a plant alkaloid obtained from the Camptotheca acuminata tree), is an anti-tumor drug with …
WebMaterial Name: Topotecan Injection Trade Name: Not applicable Chemical Family: Not determined Intended Use: Pharmaceutical product used as Antineoplastic 2. HAZARDS … WebThe drug inhibits replication of rapidly dividing cells by disrupting the normal function of the nuclear enzyme topoisomerase I. The efficacy of topotecan is related to exposure time …
WebSep 21, 2016 · Purpose Single-agent intravenous (IV) topotecan is an effective treatment for small-cell lung cancer (SCLC) after failure of first-line chemotherapy. This open-label, randomized, phase III study compared oral and IV topotecan in patients with SCLC sensitive to initial chemotherapy. Patients and Methods Patients with limited- or extensive-disease … WebTopotecan is metabolized to an N-demethylated metabolite in vitro. The mean metabolite: parent AUC ratio was about 3% for total topotecan and topotecan lactone following intravenous administration. Excretion. The overall recovery of total topotecan and its N-desmethyl metabolite in urine and feces over 9 days averaged 73% ± 2% following an ...
WebTopotecan can be given in combination with other cancer drugs. During treatment you usually see a cancer doctor, a chemotherapy nurse or a specialist nurse, and a specialist pharmacist. This is who we mean when we mention doctor, nurse or pharmacist in this information. Before or on the day of treatment, a nurse or person trained to take blood ...
WebTopotecan comes as a capsule to take by mouth. It may be taken with or without food. It is usually taken once a day for 5 days in a row every 21 days. Your doctor will decide how … porter\u0027s five forces in the airline industryWebtopotecan was discontinued if the dose had been reduced to 1.0 2mg/m /day and a further dose reduction was required to manage adverse effects. Cervical carcinoma Initial dose . … op shop footscrayWebJul 30, 2024 · Salzsäure zur pH-Wert-Einstellung. Natriumhydroxid zur pH-Wert-Einstellung. In diesem Beipackzettel finden Sie verständliche Informationen zu Ihrem Arzneimittel – … op shop ferntree gullyWebFeb 1, 2004 · Initial topotecan dose; None: 1.25–1.5 mg/m 2 on days 1–5 of a 21-day course if patient is not heavily pretreated and has good performance status: Extensive prior treatment: 1.25 mg/m 2 on days 1–5 of a 21-day course; prophylactic dose reduction to 1.0 mg/m 2 may be necessary for patients porter\u0027s five forces intelWebJan 12, 2024 · IGM Resins is the leading global provider of energy curing raw material solutions to a wide variety of industries such as graphic arts, industrial coatings, … op shop fitzroyWebTopotecan is a type of chemotherapy drug called a topoisomerase 1 inhibitor. It works by blocking a chemical called topoisomerase 1. This chemical helps to separate and repair the DNA in cells when they divide. Cancer cells need to make and repair DNA in order to grow and multiply. Blocking the action of this enzyme damages the DNA and so the ... porter\u0027s five forces internal or externalWebChemocare.com uses generic names in all descriptions of drugs. Hycamtin is the trade name for topotecan. In some cases, health care professionals may use the trade name hycamtin when referring to the generic drug name topotecan. Drug type: Topotecan is an anti-cancer ("antineoplastic" or "cytotoxic") chemotherapy drug. This medication is ... op shop flipping australia